Michael Trimble


Books - Written

1. Trimble MR. Neuropsychiatry. J. Wiley & Sons, Chichester; 1981.

2. Trimble MR. Post-traumatic Neurosis. J. Wiley & Sons, Chichester; 1981.

3. Trimble MR. Biological Psychiatry. J. Wiley & Sons, Chichester; 1988.

4. Trimble MR. The Psychoses of Epilepsy. Raven Press, New York; 1991.

5. Cummings JL, Trimble MR. Concise Guide to Neuropsychiatry and Behavioural Neurology. American Psychiatric Press Inc., Washington DC; 1995.

6. Trimble MR. Biological Psychiatry. 2nd ed. J. Wiley & Sons, Chichester; 1996.

7. Cummings JL, Trimble MR. Concise Guide to Neuropsychiatry and Behavioural Neurology. 2nded. American Psychiatric Press Inc., Washington DC; 2001.

8. Trimble MR. Somatoform Disorders – a medico legal guide. Cambridge University Press, Cambridge; 2004.

9. Trimble MR. The Soul in the Brain: the cerebral basis of language, art and belief. Johns Hopkins University Press, 2007.

Books – edited

1. Reynolds EH, Trimble MR. Epilepsy and Psychiatry. Churchill Livingstone, Edinburgh; 1981.

2. Koella WP, Trimble MR. Temporal Lobe Epilepsy, Mania, Schizophrenia and the limbic system. Karger, Basel; 1982.

3. Trimble MR, Zarifian E. Benzodiazepines divided: a multidisciplinary review. J. Wiley & Sons, Chichester; 1982.

4. Trimble MR. Psychopharmacology of the limbic system. Oxford University Press, Oxford; 1984.

5. Trimble MR. New Brain Imaging Techniques and Psychopharmacology. Oxford Univeristy Press, Oxford; 1985.

6. Trimble MR. Interface between Neurology and Psychiatry. Karger, Basel; 1985.

7. Trimble MR. The psychopharmacology of Epilepsy. J. Wiley & Sons, Chichester; 1985.

8.Trimble MR. Aspects of epilepsy and psychiatry. J. Wiley & Sons, Chichester; 1986.

9. Trimble MR, Reynolds EH. What is Epilepsy? Churchill Livingstone, Edinburgh; 1987.

10. Post MR, Trimble MR, Reynolds EH. Epilepsy, Behaviour and Cognitive Function. J. Wiley & Sons, Chichester; 1988.

11. Bolwig TG, Trimble MR. The clinical Relevance of Kindling. J. Wiley & Sons, Chichester; 1989.

12. Post MR, Trimble MR, Pippenger CE. The clinical use of anticonvulsants in psychiatric disorders. Demos publications, New York; 1989.

13. Reynolds EH, Trimble MR. The bridge between Neurology and Psychiatry. Churchill Livingstone, Edinburgh; 1989.

14. Trimble MR. Chronic Epilepsy, its prognosis and management. J. Wiley & Sons, Chichester; 1989.

15. Smith D, Treiman D, Trimble MR. Advances in Neurology. Neurobehavioural problems in Epilepsy. Raven Press, New York; 1991.

16. Trimble MR. Women and Epilepsy. J. Wiley & Sons, Chichester; 1991.

17. Trimble MR, Bolwig TG. The temporal lobes and the limbic system. Wrightson Biomedical Publishing Ltd., Petersfield; 1992.

18. Trimble MR. New Anticonvulsants: Advances ub the treatment of epilepsy. J. Wiley & Sons, Chichester; 1994.

19. Trimble MR, Dodson ED. Epilepsy and quality of life. Raven Press, New York; 1994.

20. Trimble MR, Cummings JL. Contemporary Behavioural Neurology. Butterworth Heinemann; 1996.

21. Trimble MR, Schmitz B. Forced Normalization and alternative psychoses of epilepsy. Wrightson biomedical Publishing Ltd, Petersfield, UK; 1998.

22. Trimble MR, Hindmarch I. Benzodiazepines. Wrightson Biomedical Publishing Ltd, Petersfield, UK; 2000.

23. Treiman D, Schmitz B. The Neuropsychiatry of epilepsy. Cambridge University Press, Cambridge; 2002.

24. Trimble MR, Schmitz B. Seizures, Affective Disorders and Anticonvulsant Drugs. Clarius Press Ltd. Guildford, UK; 2002.

25. Trimble MR. Learning disability and Function; an integrated approach. Clarius Press, Guildford; 2003.

26. Trimble MR. Seizure Freedom. Clarius Press, Guildford; 2007.

Peer Reviewed Papers (last 100)

Ring HA, Trimble MR, Costa DC, Moriarty J, Verhoeff NP, Ell PJ. Striatal dopamine receptor binding in epileptic psychoses. Biol.Psychiatry 1994;35(6):375-80.

Ring HA, Bench CJ, Trimble MR, Brooks DJ, Frackowiak RS, Dolan RJ. Depression in Parkinson's disease. A positron emission study. Br.J.Psychiatry 1994;165(3):333-9.

Selai CE, Trimble MR. The role of Quality of Life measures in Psychopharmacology. Hum.Psychopharmacol. 1994;9:211-4.

Trimble MR. Images in Psychiatry: Hughlings Jackson. Am.J.Psychiatry 1994;151(11):1686.

Moriarty J, Costa DC, Schmitz B, Trimble MR, Ell PJ, Robertson MM. Brain perfusion abnormalities in Gilles de la Tourette's syndrome. Br.J.Psychiatry 1995;167(2):249-54.

O'Neill BA, Trimble MR, Bloom DS. Adjunctive therapy in epilepsy: a cost-effectiveness comparison of alternative treatment options. Seizure. 1995;4(1):37-44.

Schmitz B, Trimble MR. Carbamazepine and PIP-syndrome in temporal lobe epilepsy. Epilepsy Res. 1995;22(3):215-20.

Schmitz EB, Costa DC, Jackson GD, Moriarty J, Duncan JS, Trimble MR et al. Optimised interictal HMPAO-SPECT in the evaluation of partial epilepsies. Epilepsy Res. 1995;21(2):159-67.

Selai CE, Trimble MR. Quality of Life Assessment in Epilepsy: The State of the Art. J.Epilepsy 1995;8:249-54.

Trimble M. Medicine and the law: conflict or debate. J.Psychosom.Res. 1995;39(6):671-4.

Trimble MR. Introduction. New Anticonvulsant drugs and the role of clozazam as an adjunctive therapy. Human Psycho-pharmacology 1995;10:S65-S79.

UneAnong S, Trimble MR. MRI in Schizophrenia: a review of recent findings. Asian Journal of Psychiatry 1995;3:35-44.

Cockerell OC, Moriarty J, Trimble M, Sander JW, Shorvon SD. Acute psychological disorders in patients with epilepsy: a nation-wide study. Epilepsy Res. 1996;25(2):119-31.

Eapen V, Trimble MR, Robertson MM. The use of fluoxetine in Gilles de la Tourette syndrome and obsessive compulsive behaviours: preliminary clinical experience. Prog.Neuropsychopharmacol.Biol.Psychiatry 1996;20(4):737-43.

Eapen V, Trimble MR, Robertson MM. The use of fluoxetine in Gilles de la Tourette syndrome and obsessive compulsive behaviours: preliminary clinical experience. Prog.Neuro-Psychopharmacol.& Biol. 1996;20:737-43.

Mace CJ, Trimble MR. Ten-year prognosis of conversion disorder. Br.J.Psychiatry 1996;169(3):282-8.

Panico A, Parmegriani A, Trimble MR. Compulsive painting: a varient of hypergraphia? Behavioural Neurology 1996;9:177-80.

Pilo L, Ring H, Quinn N, Trimble M. Depression in multiple system atrophy and in idiopathic Parkinson's disease: a pilot comparative study. Biol.Psychiatry 1996;39(9):803-7.

Robertson MM, Scull DA, Eapen V, Trimble MR. Risperidone in the treatment of Tourette syndrome: a retrospective case note study. Journal of Psychopharmacology 1996;10(4):317-20.

Thomas L, Trimble M, Schmitz B, Ring H. Vigabatrin and behaviour disorders: a retrospective survey. Epilepsy Res. 1996;25(1):21-7.

Thomas L, Trimble M. The effects of vigabatrin on attention, concentration and mood: an investigation in healthy volunteers. Seizure. 1996;5(3):205-8.

Trimble M. Behavioural complications of limbic epilepsy: implications for an understanding of the emotional motor system in man. Prog.Brain Res. 1996;107:605-16.

Trimble MR. Anticonvulsant-induced psychiatric disorders. The role of forced normalisation. Drug Saf 1996;15(3):159-66.

Varma AR, Moriarty J, Costa DC, Gacinovic S, Schmitz EB, Ell PJ et al. HMPAO SPECT in non-epileptic seizures: preliminary results. Acta Neurol.Scand. 1996;94(2):88-92.

Chi-Wan Lai, Trimble MR. Stress and Epilepsy. J.Epilepsy 1997;10:177-86.

Matsuura M, Trimble MR. Zonisamide and Psychosis. J.Epilepsy 1997;10:52-4.

Moriarty J, Eapen V, Costa DC, Gacinovic S, Trimble M, Ell PJ et al. HMPAO SPET does not distinguish obsessive-compulsive and tic syndromes in families multiply affected with Gilles de la Tourette's syndrome. Psychol.Med. 1997;27(3):737-40.

Moriarty J, Varma AR, Stevens J, Fish M, Trimble MR, Robertson MM. A volumetric MRI study of Gilles de la Tourette's syndrome. Neurology 1997;49(2):410-5.

Schmitz EB, Moriarty J, Costa DC, Ring HA, Ell PJ, Trimble MR. Psychiatric profiles and patterns of cerebral blood flow in focal epilepsy: interactions between depression, obsessionality, and perfusion related to the laterality of the epilepsy. J.Neurol.Neurosurg.Psychiatry 1997;62(5):458-63.

Shetty T, Trimble MR. The Bear Fedio Inventory: Twenty Years On. J.Epilepsy 1997;10:254-62.

Trimble MR, Mendez MF, Cummings JL. Neuropsychiatric symptoms from the temporolimbic lobes. J.Neuropsychiatry Clin.Neurosci. 1997;9(3):429-38.

Mortimore C, Trimble M, Emmers E. Effects of gabapentin on cognition and quality of life in patients with epilepsy. Seizure. 1998;7(5):359-64.

Ring HA, Moriarty J, Trimble MR. A prospective study of the early postsurgical psychiatric associations of epilepsy surgery. J.Neurol.Neurosurg.Psychiatry 1998;64(5):601-4.

Selai CE, Trimble MR. Adjunctive therapy in epilepsy with new antiepileptic drugs: is it of any value? Seizure. 1998;7(5):417-8.

Trimble M, Cutting J. Invited commentaries on: nuclear schizophrenic symptoms as a window on the relationship between thought and speech. Br.J.Psychiatry 1998;173:310-1.

Trimble MR. Patients with epilepsy and psychosis treated with vigabatrin. J.Epilepsy 1998;11:61-6.

Trimble MR, Whurr R, Brookes G, Robertson MM. Vocal tics in Gilles de la Tourette syndrome treated with botulinum toxin injections. Mov Disord. 1998;13(3):617-9.

Ring HA, Acton PD, Scull D, Costa DC, Gacinovik S, Trimble MR. Patterns of brain activity in patients with epilepsy and depression. Seizure. 1999;8(7):390-7.

Schmitz EB, Robertson MM, Trimble MR. Depression and schizophrenia in epilepsy: social and biological risk factors. Epilepsy Res. 1999;35(1):59-68.

Selai C, Trimble MR. The Validity and sensitivity of three quality of life measures used to assess outcomes in epilepsy. Epilepsia 1999;40:213.

Selai C, Trimble MR. Quality of life pre and post epilepsy surgery. Epilepsia 1999;40:183.

Selai C, Trimble MR. Assessing Quality of Life in dementia. Ageing and Mental Health 1999;3:101-11.

Selai CE, Smith K, Trimble MR. Adjunctive therapy in epilepsy: a cost-effectiveness comparison of two AEDs. Seizure. 1999;8(1):8-13.

Trimble MR, van Elst LT. On some clinical implications on the ventral striatum and the extended amygdala - investigations of agression. Annals of the New York Academy of Sciences 1999;877:638-44.

Trimble MR. Epilepsy and psychiatric disorders. Acta Neuropsychiatrica 1999;11:137-40.

van Elst LT, Woermann FG, Free SL, Thompson PJ, Trimble MR, Duncan JS. Affective aggression in patients with temporal lobe epilepsy (TLE): Reduction of frontal neocortical grey matter demonstrated using quantitative MRI. Epilepsia 1999;40:58.

van Elst LT, Woermann FG, Lemieux L, Trimble MR. Amygdala enlargement in dysthymia--a volumetric study of patients with temporal lobe epilepsy. Biol.Psychiatry 1999;46(12):1614-23.

Anhoury S, Brown RJ, Krishnamoorthy ES, Trimble MR. Psychiatric outcome after temporal lobectomy: a predictive study. Epilepsia 2000;41(12):1608-15.

Brown RJ, Trimble MR. Dissociative psychopathology, non-epileptic seizures, and neurology. J.Neurol.Neurosurg.Psychiatry 2000;69(3):285-9.

Maier M, Mellers J, Toone B, Trimble M, Ron MA. Schizophrenia, temporal lobe epilepsy and psychosis: an in vivo magnetic resonance spectroscopy and imaging study of the hippocampus/amygdala complex. Psychol.Med. 2000;30(3):571-81.

Matsuura M, Trimble MR. Psychoses in Epilepsy: A Review of Japanese Studies. Epilepsy Behav. 2000;1(5):315-26.

Selai CE, Elstner K, Trimble MR. Quality of life pre and post epilepsy surgery. Epilepsy Res. 2000;38(1):67-74.

Stern E, Silbersweig DA, Chee KY, Holmes A, Robertson MM, Trimble M et al. A functional neuroanatomy of tics in Tourette syndrome. Arch.Gen.Psychiatry 2000;57(8):741-8.

Trimble MR. Charles Lloyd: epilepsy and poetry. Hist Psychiatry 2000;11 Pt 3(43):273-89.

Trimble MR, Rusch N, Betts T, Crawford PM. Psychiatric symptoms after therapy with new antiepileptic drugs: psychopathological and seizure related variables. Seizure. 2000;9(4):249-54.

van Elst LT, Woermann FG, Lemieux L, Thompson PJ, Trimble MR. Affective aggression in patients with temporal lobe epilepsy: a quantitative MRI study of the amygdala. Brain 2000;123 ( Pt 2):234-43.

Woermann FG, van Elst LT, Koepp MJ, Free SL, Thompson PJ, Trimble MR et al. Reduction of frontal neocortical grey matter associated with affective aggression in patients with temporal lobe epilepsy: an objective voxel by voxel analysis of automatically segmented MRI. J.Neurol.Neurosurg.Psychiatry 2000;68(2):162-9.

Elstner K, Selai CE, Trimble MR, Robertson MM. Quality of Life (QOL) of patients with Gilles de la Tourette's syndrome. Acta Psychiatr.Scand. 2001;103(1):52-9.

Krishnamoorthy ES, Brown RJ, Trimble MR. Personality and Psychopathology in Nonepileptic Attack Disorder and Epilepsy: A Prospective Study. Epilepsy Behav. 2001;2(5):418-22.

Nees H, Moriarty J, Kitchen ND, Trimble MR. Psychosocial and Neurobehavioral Factors Related to Surgical Treatment for Partial Epilepsy: A Multivariate Analysis. Epilepsy Behav. 2001;2(2):135-9.

Satishchandra P, Trimble MR. On Being Seizure-Free. Epilepsy Behav. 2001;2(1):4-7.

Schrag A, Trimble M. Poetic talent unmasked by treatment of Parkinson's disease. Mov Disord. 2001;16(6):1175-6.

Selai CE, Trimble MR, Rossor MN, Harvey RJ. Assessing quality of life in dementia: Preliminary psychometric testing of thev Quality of Life Assessment Schedule (QOLAS). Neuropsychological Rehabilitation 2001;11(3/4):219-43.

Trimble MR. Epilepsy and Psychiatry - The contribution of neuroimaging studies. Epileptologia 2001;9:113-24.

Hensiek AE, Trimble MR. Relevance of new psychotropic drugs for the neurologist. J.Neurol.Neurosurg.Psychiatry 2002;72(3):281-5.

Kaiser S, Selai CE, Trimble MR. Long-term follow-up of topiramate and lamotrigine: a perspective on quality of life. Seizure. 2002;11(6):356-60.

Krishnamoorthy ES, Trimble MR, Sander JW, Kanner AM. Forced normalization at the interface between epilepsy and psychiatry. Epilepsy Behav. 2002;3(4):303-8.

Langosch JM, Trimble MR. Epilepsy, psychosis and clozapine. Hum.Psychopharmacol. 2002;17(2):115-9.

Munchau A, Bloem BR, Irlbacher K, Trimble MR, Rothwell JC. Functional connectivity of human premotor and motor cortex explored with repetitive transcranial magnetic stimulation. J.Neurosci. 2002;22(2):554-61.

Munchau A, Bloem BR, Thilo KV, Trimble MR, Rothwell JC, Robertson MM. Repetitive transcranial magnetic stimulation for Tourette syndrome. Neurology 2002;59(11):1789-91.

Trimble M. Psychopathologie des epilepsies du lobe temporal chez l'adulte. Approche Neuropsychologique Des Apprentissages Chez L'Enfant. Epilepsie, comportement et cognition 2002(68).

Trimble MR. Clinical presentations in neuropsychiatry. Semin.Clin.Neuropsychiatry 2002;7(1):11-7.

van Elst LT, Baeumer D, Lemieux L, Woermann FG, Koepp M, Krishnamoorthy S et al. Amygdala pathology in psychosis of epilepsy: A magnetic resonance imaging study in patients with temporal lobe epilepsy. Brain 2002;125(Pt 1):140-9.

Vijayaraghavan L, Krishnamoorthy ES, Brown RG, Trimble MR. Abulia: a delphi survey of British neurologists and psychiatrists. Mov Disord. 2002;17(5):1052-7.

Cramer JA, De Rue K, Devinsky O, Edrich P, Trimble MR. A systematic review of the behavioral effects of levetiracetam in adults with epilepsy, cognitive disorders, or an anxiety disorder during clinical trials. Epilepsy Behav. 2003;4(2):124-32.

Mula M, Trimble MR, Yuen A, Liu RS, Sander JW. Psychiatric adverse events during levetiracetam therapy. Neurology 2003;61(5):704-6.

Mula M, Trimble MR, Thompson P, Sander JW. Topiramate and word-finding difficulties in patients with epilepsy. Neurology 2003;60(7):1104-7.

Mula M, Trimble MR, Lhatoo SD, Sander JW. Topiramate and psychiatric adverse events in patients with epilepsy. Epilepsia 2003;44(5):659-63.

Mula M, Trimble MR. Pharmacokinetic Interactions between Antiepileptic and Antidepressant Drugs. World J.Biol.Psychiatry 2003;4(1):21-4.

Mula M, Trimble MR. The importance of being seizure free: topiramate and psychopathology in epilepsy. Epilepsy Behav. 2003;4(4):430-4.

Mula M, Trimble MR, Sander JW. The role of hippocampal sclerosis in topiramate-related depression and cognitive deficits in people with epilepsy. Epilepsia 2003;44(12):1573-7.

Satishchandra P, Krishnamoorthy ES, van Elst LT, Lemieux L, Koepp M, Brown RJ et al. Mesial temporal structures and comorbid anxiety in refractory partial epilepsy. J.Neuropsychiatry Clin.Neurosci. 2003;15(4):450-2.

van Elst LT, Krishnamoorthy ES, Baumer D, Selai C, von Gunten A, Gene-Cos N et al. Psychopathological profile in patients with severe bilateral hippocampal atrophy and temporal lobe epilepsy: evidence in support of the Geschwind syndrome? Epilepsy Behav. 2003;4(3):291-7.

Nagai Y, Critchley HD, Featherstone E, Trimble MR, Dolan RJ. Activity in ventromedial prefrontal cortex covaries with sympathetic skin conductance level: a physiological account of a "default mode" of brain function. Neuroimage. 2004;22(1):243-51.

Nagai Y, Critchley HD, Featherstone E, Fenwick PB, Trimble MR, Dolan RJ. Brain activity relating to the contingent negative variation: an fMRI investigation. Neuroimage. 2004;21(4):1232-41.

Nagai Y, Goldstein LH, Fenwick PB, Trimble MR. Clinical efficacy of galvanic skin response biofeedback training in reducing seizures in adult epilepsy: a preliminary randomized controlled study. Epilepsy Behav. 2004;5(2):216-23.

Rusch N, Trimble MR. Absence of Cortical Gray Matter Abnormalities in Psychosis of Epilepsy: A voxel-Based MRI study in patients with Temporal Lobe Epilepsy. Journal of Neuropsychiatry 2004;16:148-56.

Schrag A, Brown RJ, Trimble MR. Reliability of self-reported diagnoses in patients with neurologically unexplained symptoms. J.Neurol.Neurosurg.Psychiatry 2004;75(4):608-11.

Serra-Mestres J, Ring HA, Costa DC, Gacinovic S, Walker Z, Lees AJ et al. Dopamine transporter binding in Gilles de la Tourette syndrome: a [123I]FP-CIT/SPECT study. Acta Psychiatr.Scand. 2004;109(2):140-6.

Trimble MR. The end of the seizure can be the beginning of the problem: Epilepsy is more than just the ictus. Neurology 2004;62(5):683.
Wuerfel J, Krishnamoorthy ES, Brown RJ, Lemieux L, Koepp M, Tebartz vE et al. Religiosity is associated with hippocampal but not amygdala volumes in patients with refractory epilepsy. J.Neurol.Neurosurg.Psychiatry 2004;75(4):640-2.
Remak E, John H, Selai CE, Trimble MR, Price MJ. A cost-utility analysis of adjunctive treatment with newer antiepileptic drugs in the UK. J. Medical Economics 2004; 7: 29-40.
Gene-Cos N, Pottinger R, Barret G, Trimble MR, Ring HA. A comparative study of mismatch negativitiy (MMN) in epilepsy and non-epileptic seizures. Epileptic Disorder 2005; 7(4): 1-10.
Cavanna AE, Trimble MR. The precuneus: a review of its functional anatomy and behavioural correlates. Brain 2006; 129: 564-58.
Mula M, Sander J W, Trimble M R. The role of hippocampal sclerosis in antiepileptic drug-related depression in patients with epilepsy: A study on levetiracetam. Seizure 2006; 15, 405-408.
Orth M, Trimble M R. Friedrich Nietzsche’s mental illness – general paralysis of the insane vs. frontotemporal dementia. Acta Psychiatri Scand 2006: 1-6.
Mula M, Trimble MR. Neuropharmacological aspects of cognitive neurorehabilitation in epilepsy.Behav Neurol. 2006;17(1):69-75. Review
Trimble MR, Freeman A. An investigation of religiosity and the Gastaut-Geschwind syndrome in patients with temporal lobe epilepsy. Epilepsy and Behaviour 2006; 9: 407-414.
Critchley HD, Lewis PA, Orth M., Josephs O., Deichmann R., Trimble MR., Dolan RJ. Vagus nerve stimulation for treatment-resistant depression: Behavioral and neural effects on encoding negative material. Psychosomatic Medicine 2007; 69: 17-22.
Cavanna A E, Trimble M R, Cinit F, Monaco F. The “bicameral mind” 30 years on: a critical reappraisal of Julian Jaynes’ hypothesis. Functional Neurology 2007; 22: 1-5

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